Items like this make me all the more amused that the abbreviation for this site is WTF. If you have a mouse with a scroll wheel which is set to scroll by a certain number of lines, Adobe Reader interprets that weirdly. The only workaround I have found is to set the global preference for scrolling to go page-by-page rather than N lines. In Firefox, you can override the settings by going into about:config from the address bar and setting sysnumlines to false and other settings as appropriate (more)-- if, you know, you use Firefox primarily.
I haven't found a mouse utility that successfully overrides for Adobe Reader only. Post something if you have.
